Can UAC settings be made permanent?

I participate in the Stanford University "protein folding" distributed
computing project. I need to run a command line program called
FAH502-Console.exe. I put it in a directory in Program Files, put a shortcut
on the desktop and marked the shortcut "Run as Administrator." When I click
on the shortcut icon, I still get two warnings every time I run the program:
an unknown publisher warning (no valid digital signiture) and a UAC "unknown
program" warning. On the first warninig, I always uncheck the "ask every
time" box and click on Run. On the UAC warning, I click on continue (or
whatever). The program then runs fine. But can't I PERMANENTLY approve this
program?

BTW, same thing when I navigate to the executable and run it by clicking on
"Run as Administrator."