game stopped working

I installed Virtual Villagers: The Lost Children and it worked fine. The game
is vista compatible. I quit and shut down the computer. The next time I
started it I got the message Virtual Villagers: The Lost Children has stopped
working. I've tried changing the compatiblity, running it as administrator
and the problem report and solution centre. It just won't run. I've had this
problem with AdAware 2007 but I've got other security software running and I
really like this game! Does anyone have any idea what I can do? I've tried
the game manufacturer's website. They don't know. I'm worried this will
happen with other programs (not just games, lol) and I don't know what to do
if it does.
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Vista Home Premium
Intel Core TM 2 Duo Processor T5450 1.66GHz, 2MB Cache 667MHz
2 GB DDR-11 (677MHz)