Inheriting Permissions

I am trying to run Eudora 5.2 on Windows XP and am getting
the following error message:

Could not open the file C:\......\descmap.pce for reading

Cause: Access permission denied. File may be marked as
read only or locked (13)

I removed the 'read only' feature on the Administrator
Eudora folder but am still getting the same error.

Do I go somewhere to change permissions globally in XP?

Thanks.