Wireless Entertainment Keyboard 7000 issue - HOT KEY no workee

> I have assigned the file "E:\Tribune.xlsx" to the My Favorites 1 position.
> However, I can't seem to depress the 1/F5 key in such a way as to execute the
> file.
>
> Specifically, depressing that key and holding it, should execute that file.
> The natural follow through would be to have Office Excel 2007 open with the
> file loaded.
>
> Any ideas why those key assignments aren't working?
>
> RaXeT